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No substitute for hard work: Creatine supplementation does not improve exercise outcomes in COPD Creatine, a popular nutritional supplement renowned for enhancing athletic performance and muscle strength, does not improve exercise outcomes in patients with chronic obstructive pulmonary disease (COPD), according to a new study. The randomized, placebo-controlled, double-blind study provided the most powerful evidence to date that the effect of creatine (Cr) supplementation was negligible at best among these patients.
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