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Virus widely used in gene therapy research yields important clues to genomic instability Genomic instability—the rearrangement of chromosomes or an abnormal number of chromosomes—is a hallmark of many human cancers. Although the source of genomic instability has been established for many inherited human cancers, the processes and genes involved in cancers that that are not inherited but arise sporadically remain largely unknown. Now, researchers at the University of Pittsburgh School of Medicine say they have the ability to study the potential cause of genomic instability in sporadic cancers using a recombinant adeno-associated virus, the same virus that many researchers around the world use for gene therapy experiments. The results of their work are being presented at the 10th annual meeting of the American Society of Gene Therapy, which is being held May 30 to June 3 at the Washington State Convention & Trade Center, Seattle.
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